Study of saglina protein gene in Anopheles darlingi and other Anopheles spp and its possible relation to infectivity by Plasmodium Falciparum

Among the species of Anopheles, the mosquito that transmits the infective form of the protozoan parasite (sporozoites), the main species found in Brazil is the Anopheles darlingi which is found in 80% of Brazilian territory and, in the Amazon region is related to 99.8% of the number cases.

The saglina is a protein from the salivary gland of Anopheles that interacts with the field-A TRAP protein, sporozoite surface protein, which is essential for the interaction intrusion of the salivary gland and the transmission of malaria occur.

The objective of this study was to evaluate the variability of the gene encoding the intraspecific saglina protein in Anopheles darlingi and inter-specific in relation to other species of Anopheles found in Brazil and the possible relationship of the variability of this protein with the infectivity of mosquitoes Plasmodium falciparum.

Basic Science
Genetics and Genomics

Aug 2011 — Oct 2015

America, Southern
Brazil