Last Updated: 18/06/2024
Study on the correlation between in vitro drug resistance determination of Plasmodium vivax and drug resistance genes at the China-Myanmar border
Objectives
*The title and abstract were machine translated from Mandarin
This proposal aims to identify the chloroquine and other drugs target genes by both in vitro drug sensitivity studies and the correlation study with the variation of updates potential drug resistance genes in an attempt to identify drugs resistance targets and further to develop the molecular tools to monitor drug resistance.
China- Myanmar border is the main area where malaria is imported to China, where we have found that dramatic increases of vivax malaria cases recently. However,whether this is caused by drug resistance has not been systematically studied. The result of this study, molecular methods and processes to monitor the drugs resistance, will be valuable tools for drugs resistance monitoring. A better understanding of drug resistant in China- Myanmar border will be benefit to guide the malarial therapy and benefit monitoring malarial drug resistance, guide safe and reasonable malarial therapy.
Jan 2019 — Dec 2022
$57,827
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