Last Updated: 02/12/2024
Structure-guided molecular resolution of broadly protective immunity in malaria
Objectives
In this project, new electron microscopy methods will be used to elucidate the molecular basis of naturally acquired antibody responses protective to severe malaria to facilitate the development of new monoclonal antibody therapies and vaccines against the disease.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
Severe childhood malaria is caused by accumulation of P. falciparum malaria parasite-infected erythrocytes in the host´s microvasculature. Parasites bind the human receptor, EPCR, via their polymorphic PfEMP1 adhesion proteins. Exposed individuals develop immunity by acquisition of antibodies to PfEMP1´s EPCR-binding CIDRα1 domain, and a vaccine targeting the CIDRα1 domain could save more than 400.000 lives annually.
Themes
Date
Jan 2024 — Dec 2026
Total Project Funding
$434,064
Funding Details
Project Site
Deep Dives
Related Resources
