Last Updated: 18/06/2024
Search for new anti-malarial drug targeting erythrocytic malaria parasite that is also effective against drug-resistant strains
Objectives
*Original title and abstract were machine translated from Japanese
This proejct aims to create a lead compound based on compound X, which may exhibit antimalarial activity through a unique mechanism not found in existing drugs.
In addition to conducting various pharmacological and non-pharmacological tests of compound X, which was found to have antimalarial activity, and derivatives synthesized so far, construct an assay system related to mechanism of action that can evaluate SAR. . Based on the obtained evaluation results and data on resistant strains under analysis, the mechanism of action of compound X will be clarified in more detail. Furthermore, we aim to create lead compounds based on these results. The aim is to identify novel drug targets that bind to compound X. The specific contents of the experiment are as shown in 1-5 below. 1. Target identification from compound X-interacting candidate molecules. 2.Search and identification of compound X-interacting candidate molecules using compound-resistant and susceptible malaria strains 3.Acquire SAR by structural transformation of compound X. Also, the quality of compound X as a lead is evaluated from the results of the above items. 4. Biological evaluation systems that can be applied to compound screening will be studied. A drug discovery target search will be conducted aimed at searching for new malaria drugs targeting erythrocytic stage malaria parasites that are also effective against drug-resistant strains.
Apr 2019 — Mar 2023
$799,010
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