Last Updated: 01/10/2025
Regulation of Gene Expression through Higher-Order Genome Structure by the RNA-Binding Transcription Factor PREBP in Malaria Parasites
Objectives
The main aim of this study is to determine how PREBP regulates stage-specific gene expression in malaria parasites through interactions with non-coding RNA and nuclear repositioning during intraerythrocytic development.
National Center for Global Health and Medicine (NCGM), Japan
In this proposed study, based on the finding that PREBP of the malaria parasite, identified as a novel transcription factor with an RNA-binding domain, changes its localization pattern within the nucleus as the intraerythrocytic parasitic stage progresses, the hypothesis will be verified that PREBP binds to non-coding RNA and is positioned in different compartments on the genomic DNA and within the nucleus as the intraerythrocytic parasitic stage of the malaria parasite develops, thereby contributing to the control of gene expression at each developmental stage. Furthermore, the study will aim to clarify the role of changes in the three-dimensional structure of non-coding RNA and genomic DNA in the regulation of gene expression, which is essential for adaptation to intraerythrocytic parasitism.
Apr 2024 — Mar 2027
$30,043
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