Population genetics of resistance to alternative insecticides in southern Ghana

Objectives

In order to successfully apply insecticides to manage the development and spread of resistance, data are required on how best to predict the dynamics of carbamate resistance. This is the primary goal addressed by the current project.

The goal will be achieved via determination of how geographical variation in resistance to carbamates (and to a more limited extent, organophosphates) relates to, and can be predicted, by gene flow, assessed using neutral microsatellite markers, and a strongly resistance-linked mutation ace-1R. Since the predictive value of ace-1R frequencies could be compromised if alleles have independent origins, the project will also conduct long-range haplotype analysis both to determine mutational origins and to quantify the strength of selection acting on ace-1R.