Last Updated: 09/02/2026
Plasmodium vivax genomic surveillance
Objectives
The aim of this project is to improve genomic surveillance of Plasmodium vivax in malaria endemic countries.
This study provides the first high-resolution genetic picture of π. π£ππ£ππ₯ in Nepal, Bhutan, and Bangladesh, demonstrating that microhaplotype genotyping is a feasible, cost-effective tool for detecting cross-border transmission and supporting malaria elimination in South Asia and beyond.
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- Polyclonal infections were common in high-endemic settings (29.6% in Afghanistan and 20.2% in Pakistan), while all parasites from Bhutan, Nepal, and Bangladesh were monoclonal, suggesting lower superinfection.
- Country-wide Identity by Descent (IBD) analyses revealed three genetic clusters partitioning Bangladesh and Bhutan (partial) from the remaining countries.
- Two distinct sub-populations in Bhutan, separating local cases from imported cases.
Genotyping was conducted using the 93-microhaplotype vivaxGEN panel onΒ P. vivaxΒ parasites collected from patients enrolled in clinical trials in Bangladesh, Bhutan, and Nepal between 2013 and 2023. These data were compared with open-access microhaplotype and genomic data derived from Afghanistan, India, and Pakistan between 2014 and 2024. Polyclonality and relatedness (identity by descent (IBD)) were determined within and between countries.
Oct 2022 β Sep 2025
$1.5M
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