Plasmodium species co-infections in Anopheles mosquitoes: a pilot study of parasite-vector interactions that define transmission in Africa (CoMal)
The objective of this project is to define the molecular interactions associated with Plasmodium development in African malaria vectors.
Monitoring of drug resistance in Plasmodium populations is crucial for malaria control. This has primarily been performed in humans and rarely in mosquitoes where parasites genetic recombination occurs. Here, we characterized the Plasmodium spp populations in wild Anopheles vectors by analyzing the genetic diversity of the P. falciparum kelch13 and mdr1 gene fragments implicated in artemisinin and partner drug resistance across Cameroon in three major malaria vectors.