Last Updated: 27/01/2023

A pilot study to examine the persistence and immunogenicity of Plasmodium falciparum 7G8 blood stage parasites following commencement of doxycycline chemoprophylaxis

Objectives

To characterize the immunogenicity of P. falciparum 7G8 blood stage parasites following commencement of doxycycline chemoprophylaxis.
To assess the safety and tolerability of the P. falciparum 7G8 blood stage parasites.

Principal Institution

Principal Investigators / Focal Persons

Rationale and Abstract

This study involves examining the persistence and immunogenicity of P. falciparum 7G8 blood stage parasites following commencement of anti-malarial treatment with doxycycline. Participants will receive a single inoculum of purified malaria parasites followed one hour later by commencement of doxycycline treatment. Following this, we will measure the level of parasites in the blood-stream of the participants. We will also be assessing the way the immune system responds to the inoculum and the safety and tolerability of the inoculum. Characterising the persistence, immunogenicity, safety and tolerability of the malaria parasite following commencement of doxycycline treatment is important as this data may contribute to the development of novel malaria vaccine strategies.

Study Design