Last Updated: 21/11/2025

Optimisation of Controlled Human Malarial Infection by Injection of P. Falciparum Sporozoites in Non-Immune Adults (BACHMI01)

Objectives

The study is designed to establish the best dose to safely infect healthy individuals with Plasmodium falciparum sporozoites (PfSPZ) by injection.

The goal of this study is to achieve infections in human volunteers with infection rates of 100% and pre-patent periods of less than 12 days.

Principal Institution

Barcelona Institute for Global Health (ISGlobal), Spain

Principal Investigators / Focal Persons

Pedro Alonso

Rationale and Abstract

Controlled human malaria infection (CHMI) by mosquito bite is a powerful tool for evaluation of vaccines and drugs against Plasmodium falciparum malaria. However, only a small number of research centres have the facilities required to perform such studies. CHMI by needle and syringe could help to accelerate the development of anti-malaria interventions by enabling centres worldwide to employ CHMI.

Study Design

ClinicalTrials.gov ID: NCT01771848

Study Type :	Interventional (Clinical Trial)
Allocation:	Randomized
Intervention Model:	Parallel Assignment
Masking:	Single (Outcomes Assessor)
Primary Purpose:	Diagnostic