Molecular basis of variation in the sexual conversion rates of malaria parasites

Objectives

1. To identify associations between alternative pfap2-g chromatin landscapes and gametocyte conversion rates using quantitative comparative ChIP-seq experiments.
2. To develop a robust analysis pipeline for P. falciparum quantitative comparative ChIP-seq data.
3. To guide drug development efforts aimed at combating malaria by deregulating the epigenetic machinery that controls sexual conversion.