The molecular basis of female reproductive biology in the malaria mosquito Anopheles gambiae

This project aims at providing a deeper understanding of the molecular basis of reproductive biology in Anopheles gambiae females, the major vectors of human malaria, with the view to developing innovative ideas and tools for malaria control strategies based on reduction or eradication of natural mosquito populations. The analyses will be focused on the identification of the molecular factors and mechanisms that warrant sperm viability, ensure successful fertilization and affect female post-mating behaviour and physiology. This will be achieved by a comprehensive analysis of the events characterizing two major female reproductive organs: the atrium (where male seminal proteins are processed) and the spermatheca (where sperm is stored for the female life time), after copulation, in both laboratory and field settings. A variety of approaches will be employed, encompassing in depth transcriptional, proteomics and biochemical analyses of the sperm storage organs, functional assessment of the processing of male seminal fluids and its role in mosquito reproduction. This project will have a profound impact on malaria research, and will contribute to the training and scientific excellence of the next generation of scientists.

Vector Control

Apr 2011 — Aug 2014

$583,185

Europe
United Kingdom