Molecular analysis of insecticide action and resistance

The use of existing insecticides and the discovery of new insect control agents require continued research on mechanisms of insecticide action, selectivity and resistance at target sites of proven value such as the voltage-gated sodium channel. Detailed knowledge of the action of insecticides and other agents on sodium channels will contribute to the continued safe and wise use of current insecticides and the discovery and development of new insecticides acting at this high-value target. This project will employ the tools of molecular neurobiology and pharmacology to characterize mechanisms of action, selectivity and resistance of current and potential future insecticides on sodium channels.

Basic Science
Enabling Technologies & Assays
Insecticide Resistance

Oct 2012 — Sep 2017