Last Updated: 03/09/2025
Malaria Chemoprevention for the post-discharge management of severe anaemia in children in Malawi, Uganda and Kenya: Moving towards policy
Objectives
This project will look at whether routine treatment with malaria medicine through the first three months after discharge can be done in a safe and effective way. The research team will investigate this through a study in Kenya and Uganda, where children are randomized to receive three doses of the malaria medicine dihydroartemisinin-piperaquine, or three doses of placebo (oral medicine). The project will also investigate how such pre-construction can be made available in a good way. In Malawi, they will compare five ways to offer treatment to children after they are discharged from the hospital.
University of Malawi (UNIMA), Malawi
Makerere University, Uganda
Kenya Medical Research Institute (KEMRI), Kenya
Liverpool School of Tropical Medicine (LSTM), United Kingdom
London School of Hygiene and Tropical Medicine (LSHTM), United Kingdom
Imperial College London, United Kingdom
Anemia caused by malaria is one of the main reasons why young children come to hospitals in Africa, and causes a lot of disease burden and death. Many children die in the acute phase while they are still in hospital, but in addition, many homes die in the first few months after discharge. Treatment of malaria and severe anemia in hospitals is well-established practice, but no systematic routines for follow-up and treatment for the period after discharge are found.
Jan 2014 — Dec 2019
$5.32M


