Last Updated: 19/03/2025
mAb-ing acquired immunity to severe malaria
Objectives
This project will use new methods to identify broadly neutralizing antibodies and map whether these typically arise and function according to the same molecular recipe. This knowledge is important for understanding of antibody-mediated immunity to infectious diseases and will help in the development of an effective vaccine and treatment for malaria.
In areas where the malaria parasite Plasmodium falciparum thrives, people naturally develop immunity to malaria through the formation of antibodies directed against the parasite’s virulence proteins, known as PfEMP1. Although PfEMP1 proteins vary considerably in shape and composition, our new findings show that people who have been exposed to malaria can form specific cross-reactive antibodies that can bind across different PfEMP1 variants.
Oct 2024
$459,670
Related Resources
