Impact of malaria infection in pregnancy on fetal and newborn growth – Child Follow-up until 2 years of age, in relation to the fetal growth

This is an existing on-going prospective birth cohort of children born to the pregnant women who had fetal growth assessed during pregnancy. In this cohort an expected 10% of pregnant women will be exposed to malaria while the remaining will be free of malaria. Their offspring are already followed up for growth monitoring from birth until 2 years of age with anthropometric measurements including weight, length, arm and head circumference at each scheduled visit. The investigator would like to enhance the sensitivity of the study outcomes with minimal risk for the child by proposing the following anthropometric and screening tests, nutrition questionnaire, and neurodevelopment assessment. In addition a prospective cohort of children born after study approval will be followed on both protocols. The additional measure include:

• Body fat composition (at birth, and monthly up to 4 months unless weight ≥ 8kg)
• Triceps and subscapular skinfold (at 1 and 2 years)
• Anemia, malaria and soil-transmitted helminths screening (every 3 months in first 12 months and 6-monthly 1-2 years)
• Buccal swab (at 1 and 2 years)
• Neurodevelopment (every 6 months)
• Food questionnaire (at 1 and 2 years)

• Observational Model: Cohort
• Time Perspective: Prospective

ClinicalTrials.gov Identifier: NCT02800109

Clinical trial registrationSMRU info

Combination of Interventions
Vulnerable Populations

May 2016 — Feb 2018

Thailand