Last Updated

22 Jul 2021

Impact IPT With Sulfadoxine-pyrimethamine or Sulfadoxine-pyrimethamine Plus Piperaquine in Schoolchildren (PIP-IPT)

Objectives

To investigate the protective efficacy and safety of two IPTsc regimens compared with passive case detection against malaria in primary school children living in a malaria-endemic area.

Principal Investigator
Rationale and Abstract

The education sector represents a reliable system for malaria control. Intermittent preventive therapy in schoolchildren (IPTsc) is likely the most feasible and appropriate chemoprevention in stable and endemic areas because schoolchildren are usually asymptomatic to malaria infection and are consequently untreated in practice. Therefore, if proven effective, IPTsc would be of direct benefit for the schoolchild, contribute to malaria control at school, and facilitate community-wide the implementation of other control interventions i.e. vector control, Intermittent preventive therapy in infants (IPTi), and prompt diagnosis and treatment (PDT). Nevertheless, evidence about use of IPTsc is not yet substantiated as only two clinical studies have so far been performed on IPTsc in hyper endemic areas. Further clinical trials are warranted in other settings. Through a randomised controlled trial (RCT) we will assess the efficacy and safety, of two IPT regimens versus controls in school children of the DRCongo.

ClinicalTrials.gov Identifier: NCT01722539

Study Design
Study Type  : Interventional  (Clinical Trial)
Actual Enrollment  : 616 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention

Date

2012 Nov - 2013 Nov

Funding Details

Grant number: ZRDC2012 70447
Grant number: G.0978.11N
Project Site