Last Updated: 01/05/2025
Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization
Objectives
The objectives of this study are:
- To identify immune signatures that correlate with vaccine efficacy against Plasmodium falciparum, HIV-1, and SARS-CoV-2;
- To analyze variability in immune responses due to pathogen diversity, host genetics, environmental exposures, and health status;
- To advance understanding of protective immune mechanisms across diverse infectious diseases; and
- To generate insights into the complexity of the human immune system through systematic immune profiling.
Malaria, HIV/AIDS, and COVID-19 are among the most devastating infectious diseases, affecting millions of people worldwide. Effective vaccines against the pathogens responsible—Plasmodium falciparum, HIV, and SARS-CoV-2—remain elusive or limited in efficacy due to antigenic variation and other challenges, making traditional vaccine approaches insufficient for eradication. Contributing factors include an incomplete understanding of the immune responses required for protection, limitations in the ability to induce such responses, and confounding variables such as pathogen diversity, genetic variability in human populations, environmental exposures, and health status.
The projects described focus on identifying immune profiles that correlate with vaccine efficacy and are potentially relevant to protection against infection by P. falciparum, HIV-1, and SARS-CoV-2. In addition to supporting disease-specific goals, the approaches to profiling immune responses to infection and vaccination aim to uncover fundamental insights into the complexity of the human immune system. These insights are expected to inform future vaccine strategies and facilitate the development of novel therapeutic interventions for a broad range of diseases.
Jul 2017 — Apr 2027
$23.22M
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