Last Updated: 11/07/2025
Identification of drug resistant genes against partner drugs of ACT
Objectives
*Original title and text were machine translated from Japanese
This project aims to report genome-wide functional screening as a new approach to identify drug resistance genes in P. falciparum: genomic libraries of a drug-resistant strain are directly generated in drug-sensitive parasites and the drug resistance gene is then robustly identified from these libraries by drug screening.
Global spread of drug-resistant Plasmodium falciparum is a major obstacle to malaria treatment. Although the identification of drug resistance genes is crucial to efforts aimed at fighting resistant parasites, no effective approach has yet been developed.This approach was successfully to identify multi-drug-resistant transporter 7, an ATP-binding cassette transporter, as a novel mefloquine resistance gene from a field-isolated parasite strain, thus demonstrating the practical utility of the method. Genome-wide functional screening will facilitate the identification of drug resistance genes and will contribute to the global fight against drug-resistant parasites.
Apr 2017 — Mar 2020
$161,818
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