Last Updated: 03/08/2023
Identification of biomarkers for fetal growth restriction during gestational Malaria
Objectives
To identify potential biomarkers predictive of placental dysfunction in malaria in early pregnancy.
Malaria in pregnancy is characterized by the presence of Plasmodium spp. in maternal circulation, being one of the main causes of mortality in tropical regions, causing maternal anemia, abortion, premature birth, low birth weight, and Intrauterine Growth Restriction (IUGR). Therefore, IUGR is one of the main consequences of gestational Malaria, occurring in about 13% to 70% of cases. Although its prevalence and important complications associated with the infection are known, there are still no early diagnostic methods to predict IUGR caused by infection of Plasmodium spp. during pregnancy. Understanding the mechanisms present in the pathogenesis of infection during pregnancy will provide a significant contribution not only to the comprehension of the immunobiology of the disease and its complications but will also help in the development of new diagnostic, intervention, and treatment methodologies.
Jan 2022 — Aug 2025
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