Last Updated: 02/12/2024
Identification and development of proteins which interact with the innate immune system as malaria vaccine candidates
Objectives
The aim of this project is to identify the properties in a vaccine that induces antibodies capable of blocking the parasite proteins that inhibit the human proteins.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
Parasites causing malaria live inside red blood cells. Some human proteins act in a chain reaction to destroy infected cells. Although these proteins recognise parasite-infected cells and the chain reaction starts, the infected cells are not destroyed due to parasite proteins which inhibit the human proteins. A vaccine could induce antibodies which block the parasite proteins inhibiting the human proteins so the immune system can function normally and kill infected cells, thus stopping malaria.
External reference
Themes
Date
Jan 2013 — Dec 2019
Total Project Funding
$238,272
Funding Details
National Health and Medical Research Council (NHMRC) Australia, Australia
Grant ID: 7875657
AUD 299,564
Country / Project Site(s)
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