Last Updated: 30/10/2025
Health Care Provider Use ofPlasmodium vivaxRadical Cure with Tafenoquine or Primaquine After Semi-quantitative G6PD Testing: A Feasibility Study in Peru (PAVE Peru)
Objectives
The aim of the study is to investigate whether it is operationally feasible to provide appropriate treatment to P. vivax patients aged ≥6 months after G6PD testing.
Objectives:
- Assess Healthcare Provider adherence to a revised case management algorithm for vivax malaria that involves providing radical cure after semi-quantitative G6PD testing and a follow-up visit. This will be assessed at the provider, patient, and health facility level.
- Determine the ability of Healthcare Provider to safely implement radical cure after semi-quantitative G6PD testing.
- Evaluate the quality and effectiveness of training and supervision strategies to support the implementation of semi-quantitative G6PD testing before radical cure.
- Explore barriers and facilitators at the patient, provider, and facility level that mediate effective use of radical cure with semi-quantitative G6PD testing.
- Determine the costs associated with introducing semi-quantitative G6PD testing before radical cure as part of routine care.
This implementation research study will be carried out in Peru among 40 Health Care Providers (HCPs), each treating a minimum of 15 patients with P. vivax malaria. The study will be conducted in Loreto Region (Loreto, Maynas, and Ramon Castilla provinces), an area that is endemic for P. vivax.
A total of 30 health facilities will be included: 6 in the first phase, and 12 will be added in the second phase. An additional 12 health facilities have been selected as backup in case the malaria case load is low, and this is needed in order to meet the sample size.
All relevant HCPs working in study facilities will be trained on the relevant aspects of performing the G6PD testing, interpreting its result, evaluating patients’ eligibility for Radical Cure, and choosing the appropriate treatment as per their role accordingly.
ClinicalTrials.gov ID: NCT05361486
Jul 2024 — Oct 2024

