Last Updated: 18/06/2024
Haematopoietic stem cell fate and bone marrow microenvironment changes in severe infection: Cellular and molecular mechanisms
Objectives
This project has two main goals:
- To identify the mechanisms leading to the degeneration of haematopoietic stem cell (HSC) niches during severe infections, and
- To measure and improve stem cell recovery post-infection.
A murine model of severe malaria will be used, infection by Plasmodium berghei, which leads to loss of HSC function and dramatic changes to the bone marrow microenvironment. Well-established multidisciplinary research approach will be taken advantage of, combining advanced microscopy, quantitative analyses, molecular manipulations and validation through human samples, to investigate the cellular and molecular mechanisms leading to HSC niche damage, the extent of regeneration following treatment and the consequences of repeated infection/treatment cycles. Finally, molecular interventions will be tested that may preserve the HSC niche and HSC function, uncoupling HSC damage from a still active immune response.
Feb 2019 — Feb 2024
$2.07M
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