Last Updated: 29/11/2022
Genetic and molecular basis of drug resistance and drug action in vivax malaria
Objectives
To identify the genetic/molecular basis of P. vivax drug resistance in Vietnam and Cambodia and provide novel markers for the rapid detection of CQR Plasmodium vivax and new therapies targeted at reversing CQR.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
Plasmodium vivax infects ~20 million people each year. Most of these vivax malaria cases occur in the Asia-Pacific region where more than 2 billion people are at risk of infection. Unfortunately resistance to the first line treatment for vivax malaria; (chloroquine) is rapidly spreading though South East Asia. Tools to reliably detect the spread of P. vivax chloroquine resistance (CQR) and determine its sensitivity to new therapeutics are urgently needed.
External reference
Date
Jan 2017 — Oct 2020
Total Project Funding
$306,000
Funding Details
Country / Project Site(s)
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