Feasibility of Conducting Human Sporozoite Infection and Challenge Studies in Healthy Adult Malaria Naive Volunteers

Objectives

This feasibility study protocol identifies two types of studies planned in future: Infection studies and Challenge studies. The primary objective of Infection study is to standardize the P. falciparum infection model in healthy adults while the primary objective of Challenge study will be to test the efficacy of malaria vaccines using the infection model. Since the Infection/Challenge Studies are being planned for the first time in India, conducting a feasibility study is necessitated. The information obtained from this feasibility study will be used to design Sporozoite Infection and Challenge Studies with human volunteers