Last Updated: 06/10/2025
Elucidation of lipid peroxide removal pathway in erythrocytic stage malaria parasites
Objectives
The main goal of this study is to analyze the lipid peroxide metabolic pathway in erythrocytic malaria parasites and clarify the survival strategy of malaria parasites under high oxidative stress by making the most of the unique technology and bioresources established by the researcher’s laboratory.
Malaria parasites at the erythrocytic stage grow while being exposed to high oxidative stress caused by reactive oxygen species (ROS) derived from hemoglobin. In particular, lipid peroxides, which are generated by the reaction of ROS with lipids, are highly cytotoxic and induce reduced flexibility of cell membranes, DNA damage, and programmed cell death. Therefore, a metabolic pathway that removes harmful lipid peroxides is necessary. However, research on the lipid peroxide metabolic pathway in malaria parasites has hardly progressed.
Apr 2025 — Mar 2027
$30,898
