Development “patch” containing the combination of artemether – Lumefantrine for the treatment of malaria caused by Plasmodium falciparum

This work proposes the development of a transdermal patch “patch” for the treatment of malaria in order to increase patient adherence to treatment and thus assist in reducing malaria mortality rates in the world. They will be used as antimalarial agents artemether and free or encapsulated in nanoparticles lumefantrine.

For the development of nanoparticles will be used intersection techniques or self assembly. Transdermal patches are designed with different abilities release. Quantitative and qualitative analysis of adhesives substances shall consist of high-performance liquid chromatography and / or mass spectrometry. The nanoparticles will be evaluated using the dynamic light scattering techniques and scanning electron microscopy. It will also be assessed permeability to water vapor permeation, stability testing and microbiological assessments.

Drug-based Strategies
Enabling Technologies & Assays

Apr 2015

Nanotechnology to combat malaria