Last Updated: 28/03/2025
Development of the method for functional screening of RIFIN
Objectives
*Original title and text were machine translated from Japanese.
In this study, the aim is to construct a library that artificially expresses all RIFIN genes, and then screen for interactions with immunosuppressive receptors to identify target receptors for all RIFINs.
Plasmodium falciparum is the most pathogenic parasite to humans, causing hundreds of thousands of deaths annually due to fever, splenomegaly, and severe coma. When the parasite infects host red blood cells, it transports and expresses RIFIN on the surface of the infected red blood cells, thereby suppressing the function of host immune cells. This study will provide clues to fully understand the immune evasion mechanism used by the parasite.
Jun 2024 — Mar 2026
$42,929
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