Last Updated: 01/10/2025
Development of expression vectors using Toxoplasma and their application to malaria vaccines
Objectives
This project aims to overcome the long-standing problem of not being able to obtain sufficient quantities of infectious stage parasites by developing a parasitophorous vacuole membrane protein expression vector using the closely related parasite Toxoplasma gondii, which has low pathogenicity and can be recovered in large quantities, and to elucidate the host-parasite interaction.
The parasitophorous vacuole membrane, which separates the malaria parasite from the host cell within the hepatocyte, is the interface between the host and the parasite, and is a key structure for understanding the molecular basis of the establishment of human infection with the malaria parasite. This is not only useful as a tool for the first comprehensive elucidation of the molecular basis of the establishment process of human infection with the malaria parasite, but is also expected to enable screening of target molecules for infection-blocking vaccines.
Jun 2024 — Mar 2027
$42,060
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