Last Updated: 03/10/2025
Development of cell surface analysis techniques based on the cell adhesion structure of malaria parasites
Objectives
This study aims to establish a technology that will enable (1) labeling of cell surfaces, (2) conditional intercellular adhesion, and (3) modification of cell surface structures by simply creating AMA-1-expressing cells of animals, plants, and protists and adding RON2-effector peptides from the outside.
The strong intercellular adhesion formed when malaria parasites invade host red blood cells is established by hydrophobic bonds between only two types of molecules: AMA-1 on the parasite side and RON2 mounted on the red blood cell side. If the aim of this study is realized, for example, it will be possible to express AMA-1 as a fusion molecule with a fertilization factor of gamete cells and administer RON2 peptide fused with a biotinylation enzyme to screen unknown molecules related to fertilization by biotinylation.
Apr 2025 — Mar 2028
$30,892
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