Last Updated: 16/06/2022
Development, characterization and application of CRISPR/Cas9 gene drive technologies and related active genetic elements to benefit research and society at large
Objectives
To build and characterize in Drosophila melanogaster three categories of active genetic elements:
- Full MCR-gene drives.
- Split, “transcomplementing-MCR”, an alternative that could offer advantages when performing population modification in the wild.
- Reversal constructs to stop, limit or reverse the spread of a Cas9-based gene drive in the wild.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
Gene drive mechanisms increase the chance that a genetic characteristic is inherited by its progeny. We have developed a highly efficient gene drive system in the fruit fly and adapted it to the disease-vector mosquito Anopheles stephensi, where it faithfully transmits a malaria- resistance gene to nearly all progeny. The developed system has tremendous potential in benefit research, global eradication of vector-borne diseases and restoration ecosystems from invasive species.
External reference
Date
Sep 2016 — Aug 2021
Total Project Funding
$1.93M
Funding Details
National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), United States
Project Number: 5DP5OD023098-03
Country / Project Site(s)
Deep Dives
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