Developing the evidence for and assessing the feasibility of malaria elimination efforts among mobile migrant workers in plantation settings in Cambodia and Myanmar
The main objective of this project is to develop a deeper evidence base on the scale of malaria prevalence among this sub-population of mobile migrant plantation workers (MMPs), including determining the extent to which the K13 resistance propeller gene was present in individuals with Plasmodium falciparum parasitaemia.
- To determine the prevalence of malaria among mobile and migrant plantation workers, including what species is most prevalent and if the resistance gene is found in parasitemic individuals.
- To determine risk factors unique to this population, including possible transmission sites.
- To test different active 'screen and treat' models in selected plantations to identify the most cost-effective, sustainable, and operationally feasible test and treat approaches for plantation workers.
- Approach 1: Screen and treat on arrival and on exit from the plantation
- Approach 2: Screen and treat all workers at fixed intervals, such as every three months
- Approach 3: If epidemiological data demonstrate that the majority of workers harbour malaria parasites, MDA in one site may be done. MDA was to be conducted in one location if epidemiological data demonstrated that a high proportion of workers were parasitaemic. The results of the study showed very low-level parasitemia across the population, so no MDA was finally deployed.
- Target size & population: 40 plantations in 5 provinces including temporary workers (live or work on the plantation for <6 months), permanent workers, small plantation workers and big plantation workers. Family members of the selected workers (>5 years of age).
- Outcome measure: Parasite prevalence (RDT and PCR).
Intervention model: Parallel assignment
Masking: None (open label)
Primary purpose: Treatment