Last Updated: 26/07/2016
Developing a combined Rapid Diagnostic Test (cRDT) for blood-stream bacterial infections and malaria in children: A tool for improving diagnosis of non-malarial fevers and rational use of antibiotics in rural setting
Objectives
This pilot study attempted to generate preliminary evidence for an innovative strategy to identify the potential biomarkers for bacterial sepsis that could be used to develop a rapid, point-of-care test for bacterial sepsis.
Bacterial infection of the blood is a major cause of death and morbidity among children less than five years old, particularly in resource-limited settings. Blood culture is the gold standard for diagnosis of bacterial sepsis – a technique that is virtually absent in resource-limited settings. In order to reduce mortality, antibiotic therapy is normally initiated without adequate evidence. The investigators for this pilot project hypothesized that a combination of biomarkers with moderate diagnostic threshold could result in an improved ‘multistix’ for diagnosis of bloodstream bacterial infection.
Mar 2014 — Aug 2015
$90,317
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