Determinants of Mass Drug Administration (MDA) impact and design of MDAs towards malaria elimination
The aim is to present an individual based, spatially explicit model of Plasmodium falciparum malaria transmission that includes all the programmatic implementation details of mass drug administration (MDA) campaigns.
Our research questions are threefold: 1) what is the relevance of logistical implementation details to the outcome of mass interventions? 2) How fast does target coverage need to be reached for the strategy to be successful? 3) What are the key modulators of malaria elimination likelihood in a short timeframe? To offer strategic guidance to national malaria control programmes we also need to understand how the answers to these questions hinge on key features of malaria transmission in specific areas such as artemisinin resistance levels, population mobility networks, transmission heterogeneity over space, and seasonality patterns.
Computational modelling is used to explore the relationships between logistical aspects of MDA implementation and demographic aspects such as human population mobility in diverse epidemiological settings (characterized by prevalence, seasonality patterns and heterogeneity in mosquito densities across space).