Last Updated: 02/12/2024
Designing a scalable vaccine to induce liver resident T cells against malaria
Objectives
To understand the vaccine mechanism in more detail in order to optimize design, and to evaluate newly defined Plasmodium falciparum antigens to target with the vaccine, with the aim of eventual translation in humans.
Gavin Painter
Susanna Chan
Sarah Draper
William Heath
Ian Hermans
Preliminary data in animals have shown that long-lived protective immunity against the infectious Plasmodium species that cause malaria can be elicited with vaccines that induce parasite-specific T cells that form a resident population in the liver. This was achieved with novel synthetic glycolipid-peptide conjugates that exploit the function of glycolipid-reactive NKT cells. This project will provide better understanding of the mechanism and help translate it to humans in the future.
Jan 2020 — Jan 2023
$810,000
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