Last Updated: 31/01/2025

Delivery of Malaria Chemoprevention in the Post-discharge Management of Children With Severe Anaemia in Malawi (PMC)

Objectives

The overall goal of this project is to design and evaluate an effective delivery mechanism for post-discharge malaria chemoprevention (PMC) within the health system.

The primary objective is to determine the optimum PMC delivery mechanism by comparing community- versus health facility-based strategies in order to inform policy.

Principal Institution

University of Bergen, Norway
University of Malawi (UNIMA), Malawi

Principal Investigators / Focal Persons

Kamija Phiri

Partner Institutions

Makerere University, Uganda
Liverpool School of Tropical Medicine (LSTM), United Kingdom
Kenya Medical Research Institute (KEMRI), Kenya
University of Amsterdam, The Netherlands
Imperial College London, United Kingdom
Ministry of Health (MOH) Malawi, Malawi

Rationale and Abstract

In malaria-endemic countries of sub-Saharan Africa, many children develop severe anaemia due to previous and current malaria infections. After blood transfusions and antimalarial treatment at the hospital, they are usually discharged without any follow-up. In the post-discharge period, these children may contract new malaria infections and develop rebound severe anaemia.

ClinicalTrials.gov Identifier: NCT02721420

Study Design

Study Type :	Interventional (Clinical Trial)
Estimated Enrollment :	375 participants
Allocation:	Randomized
Intervention Model:	Factorial Assignment
Masking:	None (Open Label)
Primary Purpose:	Prevention