Combining indoor residual spraying and long-lasting insecticidal nets for malaria prevention: a cluster randomized controlled trial in Ethiopia (Maltrials)

Objectives

This proposal aims to assess whether the combined use of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) increases protection against malaria. The proposal is to conduct a cluster randomised controlled trial in Ethiopia to measure malaria incidence and transmission, insecticide resistance, and to assess whether mosquito nets result in an age shift in malaria morbidity before and after trials. We plan to do the research in the Adami Tullu area in the Ethiopian Rift Valley. The intervention will consist of four “arms”: (IRS+LLINs, LLINs alone, IRS alone and control (routine practice)).The village is the unit of randomisation. The cost-effectiveness study will be performed prospectively alongside the trial.