Last Updated: 13/05/2026
Coil-like structure in Plasmodium gametocyte: IMC molecules involved in the unknown cytoskeleton?
Objectives
The project investigates the coil-like structures formed by Inner Membrane Complex (IMC) proteins in Plasmodium gametocytes, suggesting their role in an unknown cytoskeleton during the sexual stage in mammalian hosts.
Some moelcules reported to be Inner Membrane Complex (IMC) proteins and others stand out in Plasmodial gametocyte cells, showing coil-like structure. These and other IMC molecules can collectively form unknown cytoskeleton in the sexual stage in mammalian hosts. Following 3 questions were raised to analyse the molecules: 1. Any interacting partner molecules? 2. How unexamined molecules behave in gametocyte? 3. Any change in phenotype if the molecule(s) ot interacting molecules are deleted? The antibodies raised against some previously unexamined molecules on fixed gametocyte cells show coil-like structure.
Apr 2015 — Mar 2019
$44,022
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