Last Updated: 26/06/2015
Characterisation of insecticide resistance in Ugandan populations of Anopheles funestus major malaria vector
Objectives
As a contribution toward the improvement of our ability to control malaria in Uganda, the aim of this proposal is to characterise insecticide resistance in field populations of An. funestus in this country. The project encompasses three aims:
- To assess the extent and distribution of insecticide resistance in field populations of An. funestus throughout Uganda,
- To characterise mechanisms of pyrethroids and DDT resistance in An. funestus populations from Uganda using a microarray chip recently designed for this species,
- To analyse the genetic structure of An. funestus populations in Uganda in order to assess the extent of gene flow between these populations using microsatellites loci.
Liverpool School of Tropical Medicine (LSTM), United Kingdom
Resistance to pyrethroids and DDT was recently observed in An. funestus population from eastern Uganda prompting fears that unless barriers to gene flow exist, this resistance front could rapidly spread throughout Uganda and neighbouring countries such as Kenya and disrupt malaria control programs.
However, little is known about the extent, distribution and mechanisms of this resistance throughout the country. Such information is crucial for the successful implementation and management of control programs against this important malaria vector.
Sep 2010 — Feb 2013
$153,882
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