Last Updated: 28/05/2025
Biomedical studies and cellular imaging via atomic force microscopy
Objectives
This project aims to continue working on characterizing Plasmodium falciparum circumsporozoite protein (CSP) and extracted lipid rafts to improve mechanistic understanding of the malaria parasites and pathogen-host interactions.
Selective biological atomic force microscopy (Bio-AFM) platforms have been continously developed along with Quartz Crystal Microbalance-Dissipation (QCM-D), optical microscopy and spectroscopies. In collaboration with NIH intramural and extramural scientists, this project will work toward broader and more insightful biomedical applications of multifunctional, multimodal, AFM imaging and single-molecule force spectroscopy (SMFS) for cellular and macromolecular studies. On biomedical applications, broad range of collaborations have been going on that include a commitment to developing a better clinical vaccine toward enhanced immunological response and eventual eradication of malaria. Over several years and via Bio-AFM and related bioanalysis, the macromolecular structure and nanomechanical properties of more malaria vaccine candidates have been investigated.
Jan 2007 — Dec 2020
$3.33M
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