Last Updated: 11/07/2025
Antigenic variation can change T cell immunity in malaria?
Objectives
*Original title and text were machine translated from Japanese
The research investigates how genetic diversity in malaria parasites and host immune responses, particularly HLA genes, affects T cell immunity in malaria.
It is well considered that the diversity not only in host immune response including HLA but also the malaria parasite genes are involved in the interaction of pathological situation. In order to elucidate the pathogenic mechanism of malaria infection, this project analyzed the genetic polymorphisms of parasite genes targeted as vaccine candidate and major HLA genes by using the next generation sequencing (NGS) analysis method. To observe the genetic variation in a small area of Philippines, genomic sequences of the genes isolated from peripheral blood of 82 patients with symptomatic malaria was determined in Palawan Island. After NGS, 78 out of 82 individuals showed reasonable quality for the analysis, ranged from 11,536 to 188,248 reads per gene per sample. When the levels of polymorphism in each gene was estimated, in the TAM gene, 6 alleles were assigned in the population, and 2 alleles were newly classified. The population base study of malaria genome will give us thus useful informations.
Apr 2017 — Mar 2020
$161,818
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