Last Updated: 12/12/2025
Antigen presentation in cerebral malaria pathogenesis: A role for brain microvascular endothelium and microparticles
Objectives
This project aims to investigate the role of brain microvascular endothelial cells in the pathogenesis of cerebral malaria, particularly how they function as immune cells that activate T lymphocytes and contribute to inflammation.
This project aims to better understand how lesions occur in the brain during cerebral malaria. It will focus on the cells lining the brain blood vessels, called endothelial cells. The originality of this project is to study endothelial cells as immune cells. It has already been showed that they carry molecules enabling them to activate T lymphocytes and trigger inflammation. Knowing the fine mechanisms by which small brain vessels become damaged will help design better treatments for neuroinflammation.
Jan 2016 — Dec 2018
$312,839
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