AFRO II project: Evaluating the feasibility and impact on malaria transmission of community-based winter larviciding in Namibia, Botswana and Eswatini
To evaluate the feasibility and impact of community-based winter larviciding using biological agent Bacillus thuringiensis var. israelensis (Bti; VectoBac®) on malaria transmission in southern African countries aiming for malaria elimination.
• To assess whether winter larviciding combined with IRS prior to the rainy season reduces vector adult density inside and outside houses when compared with IRS alone
• To assess whether winter larviciding combined with IRS prior to the rainy season provides added protection against clinical malaria when compared with areas that receive IRS alone
• To determine whether the combined interventions reduce the proportion of aquatic habitats containing Anopheles larvae not only during the intervention but also when larviciding is not implemented (spill-over effect, synergistic effect with IRS)
Intervention assignment: Parallel (different groups receive different interventions at same time during study).
Allocation to intervention: Randomised (simple randomization using a table created by a computer software program).
How the sequence/code was concealed from the person allocating the participants to the intervention arms: Determined by the holder of the sequence who is situated off site.
Masking: Open-label (Masking Not Used)