Last Updated: 10/07/2025

A study towards establishing a cell line depleted of mitochondrial DNA in malaria parasites

Objectives

*Original title and text were machine translated from Japanese

This project aims to elucidate transcriptional and translational mechanisms of mitochondrial DNA (mtDNA) mechanisms in malaria parasite. This project generated a cell depleted of mtDNA using ethidium bromide (EtBr) in malaria parasites.

Principal Institution

Chiba University, Japan

Principal Investigators / Focal Persons

Kenji Hikosaka

Rationale and Abstract

In malaria parasites, transcriptional and translational mechanisms of mitochondrial DNA (mtDNA) remain unclear. This study showed that the human malaria parasite has higher sensitivity to EtBr compared with a rodent malaria parasite. These findings would provide a valuable information to a study towards establishing a cell line depleted of mitochondrial DNA in malaria parasites.

External reference

Project details

Themes

Basic Science

Date

Apr 2017 — Mar 2020

Total Project Funding

$37,792

Funding Details

Japan Society for the Promotion of Science (JSPS), Japan

Grant ID: 17K15676

JPY 4.16M