Last Updated: 30/10/2025
A mixed-method operational research study on the use of tafenoquine and G6PD testing for radical cure ofPlasmodium vivaxmalaria in passive and active case detection in Vietnam (PAVE Vietnam)
Objectives
The goal of this study is to generate evidence to assess whether the use of tafenoquine (TQ) for radical cure (RC) of P. vivax malaria is operationally feasible in Vietnam (a country approaching malaria elimination).
Primary objective: assess adherence to a revised case management algorithm for P. vivax malaria in passive, reactive, and proactive case finding strategies.
Secondary objectives:
- Determine the capacity of the health system to safely implement RC treatment after G6PD testing.
- Assess the quality and effectiveness of training, monitoring, and supervision strategies through competency testing and supervision evaluations.
- Explore barriers and facilitators to adding TQ to the treatment algorithm in different case finding strategies.
- Determine the costs associated with introducing a single-dose TQ.
- Monitor the frequency of new malaria infections in study participants.
Exploratory objective: monitor moderate and severe adverse events in P.vivax patients receiving RC.
National Institute of Malaria, Parasitology and Entomology (NIMPE) Vietnam, Vietnam
PATH, United States
Medicines for Malaria Venture (MMV), Switzerland
Malaria is a big health issue in many countries around the world. Among the six types of parasites causing malaria in humans, Plasmodium vivax (P. vivax) is the second most common after P. falciparum, and it’s found in the widest range of places. According to the World Health Organization (WHO), there were about 6.4 million cases of P. vivax malaria globally in 2019. P. vivax infection is marked by the persistence of dormant parasites (called liver-stage hypnozoites), leading to recurring malaria episodes months or even years after the first infection.
ISRCTN15552312
Study design: Prospective longitudinal operational study with mixed-methods approach including qualitative component quantitative component and costing component
Primary study design: Observational
Secondary study design: Longitudinal study
Study setting(s): Hospital, Medical and other records, Other
Study type: Diagnostic, Treatment
Mar 2025 — Sep 2025
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