Last Updated: 28/01/2025
4D reconstruction of de novo cristae formation in malaria parasite mitochondria
Objectives
In this project the investigators will employ cutting-edge live-and electron microscopy to provide an unparalleled 4D-reconstruction of cristae formation in malaria parasite mitochondria. By combining these insights with data on protein complexes, they will shed light on this validated antimalarial drug-target and on basic principles of cristae formation.
Radboud University Medical Center (Radboudumc), The Netherlands
The inner membrane of mitochondria, the powerhouses of the cell, is characterized by invaginations, termed cristae. Malaria parasites harbour a single, unusual mitochondrion that lacks cristae during the pathogenic blood-infection. After formation of sexual-stage parasites, required for transmission to the mosquito vector, mitochondrial functioning changes dramatically and cristae are formed from scratch.
Nov 2022 — Oct 2027
