Last Updated: 04/12/2025
Elucidation of the mechanisms of RON3 during sporozoites invasion of hepatocytes
Objectives
*Original title and text were machine translated from Japanese
The aim of this study is to elucidate the molecular mechanisms of sporozoite invasion by focusing on RON3, the secretory protein stored in rhoptries in both merozoites and sporozoites.
Malaria transmission to humans initiates by sporozoite infection of hepatocytes, which are inoculated by infected Anopheles mosquitoes. To develop the infection inhibitory vaccines, the step of sporozoite invasion of hepatocytes is one of the ideal targets, however its molecular mechanisms are not elucidated clearly. By generating sporozoite stage-specific RON3 conditional knockdown parasites in Plasmodium berghei, RON3 functions during sporozoite invasion was investigated in vitro and in vivo. Moreover, specific antibodies against partial recombinant RON3 were raised in rabbits to examine their inhibitory effects on sporozoite infection.
Apr 2016 — Mar 2019
$158,891
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