Last Updated: 02/12/2025
Protein localisation and expression of a novel cell cycle gene in rodent malaria parasite
Objectives
This research proposed to study the expression of the novel cyclin CYC1 during the Plasmodium life cycle using cell biological and biochemical approaches using the rodent malaria model, P. berghei. This information will aid in future research about the role of unique cyclin in Plasmodium.
Cell division and its regulation are well studied in many organisms, including yeast, plants, and humans. Progression through the cell cycle is coordinated by components including cyclins, kinases, and phosphatases. The recent studies on kinases and phosphatases in Plasmodium have identified essential regulators in parasite development. (Guttery et al., 2014; Tewari et al., 2010). Presently, our understanding of the role of cyclins during the malaria cell cycle and how they control cell division is poor. Recently, three cyclin genes have been identified, and the function of cyclin 3 has been elucidated (Roques et al., 2015). The Plasmodium cell division resembles endomitosis in asexual stages (schizogony, sporogony) and an endocyling division during sexual development in male gametogenesis (Guttery et al., 2012).
Jun 2016 — Aug 2016
$2,024
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