Last Updated: 01/10/2025
Elucidation of the genetic background for the spread of drug-resistant malaria
Objectives
This study aims to investigate phenotypic differences between two resistant parasite strains from Uganda and to identify novel genetic mutations that may contribute to their spread.
Since the discovery of resistant parasites to first-line malaria drugs, two resistant parasites, Kelch13C469Y and A675V, have appeared in Uganda. Currently, C469Y, which has low resistance to artemisinin, is spreading, surpassing A675V, which has high resistance to artemisinin. This phenomenon is known to occur in resistant parasites in Southeast Asia, but the reason why this phenomenon occurs is unknown. The researcher believe that drug-resistant parasites have a phenotype that allows them to spread in addition to the strength of resistance.
Apr 2024 — Mar 2027
$24,890
Related Resources
