Last Updated: 16/06/2026
Effector export in P. falciparum infected human erythrocytes
Objectives
This project will explore how the parasite identifies, invades and remodels the host cells in which it lives, scavenging nutrients and hiding from the immune system.
Principal Institution
Walter and Eliza Hall Institute of Medical Research (WEHI), Australia
Principal Investigators / Focal Persons
Partner Investigators
Rationale and Abstract
This project will investigate malaria, a parasitic disease that kills over 450,000 people a year. It will characterize the proteins involved in these critical events, as they are potential targets for drugs. It will study how parasites cause disease and how the host responds to infection.
Project Outputs
- · Article: 4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation - [Nat Commun, 2021]
- · Article: Formation of the moving junction is the nexus for host cytoskeletal remodelling during Plasmodium falciparum invasion of human erythrocytes - [bioRxiv, 2026]
External reference
Themes
Date
Jan 2017 — Dec 2020
Total Project Funding
$772,427
Funding Details
National Health and Medical Research Council (NHMRC) Australia, Australia
Grant ID: 1121178
AUD 1.07M
Country / Project Site(s)
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